| David Marcey Office Hours or availability for appointment: see DM's schedule |
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Subject Material: The elaborate interplay of a variety of macromolecules underlies the mechanisms that govern cell function. This advanced, 2 unit seminar course deals with the structure-function relationships of these macromolecular machines. It is intended that students emerge from this course with a deep understanding of the principles that govern macromolecular structure and the functional consequences of these principles. See learning goals, below. This course assumes a good understanding of basic molecular biology. See DM if you think you might require some remedial reading in this area. |
Text: Additional Reading: Journal Articles on the structure of macromolecules |
Supplemental Learning Material: You will also be provided additional learning aids that are accessable on the WWW or on the local CLU network. See linked resources, below. |
Grading: The grade for this class will be determined solely by the quality of the completed web tutorial and on the quality of an oral presentation delivered in public. The WWW tutorial construction assignment involves building a molecular tutorial in an HTML (HyperText Markup Language) document. You may choose your own molecule in consultation with DM. You will need to learn the RasMol/Chime scripting language to build your tutorial. Instruction on tutorial construction will be provided in the first few weeks of class. More information on the project assignment can be found here. |
Academic Honesty and Class Conduct: It is you responsibility to know the guidelines of the university regarding academic honesty and class conduct. READ THE SECTION ON ACADEMIC HONESTY in the CLU COURSE CATALOG to familiarize yourself with the CLU policies, as this course will follow these guidelines. Please be reminded that if you use the words of another person, whether or not you scientifically cite the source in your text, you also must use quotes around those words. It is important to learn to use your own writing to present ideas and syntheses of ideas. You should read the CLU guide to avoiding plagiarism! |
Learning Disabilities: If you have a disability and therefore may have need for some type of accommodation(s) in order to participate fully in this class, please feel free to discuss your concerns in private with me AND BE SURE TO CONTACT the learning center. |
Goals | Assignments & Assessment |
To learn about:
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reading, course lectures, discussions, |
To learn to use the hypertextual medium of the World Wide Web as a way to present ideas. | web project |
To hone written and oral communication skills. |
web project and class discussions |
DATE | TOPIC | READING | ASSIGNMENTS | |
Aug | 28 | Introduction to Course | ||
Sep |
4 |
Basic Principles of Protein Structure |
Chapters 1 & 2 | explore PDB |
Sep |
11 | Motifs, Structures, Folding - Web page fomat | Chapters 3-6 | work on molecule of choice |
Sep |
18 |
Tutorial construction |
| pick molecule |
Sep |
25 | Nucleic Acid Structures |
Chapter 7, read articles on molecule of choice | one page write up on molecule |
Oct |
2 |
DNA recognition | Chapter 8, read articles on molecule of choice |
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Oct |
9 |
Transcription Factor Binding |
Chapter 9, read articles on molecule of choice | oral presentation to the class of key structural features of the molecule of choice |
Oct |
16 | Transcription Factor Families |
Chapter 10, read articles on molecule of choice | |
Oct |
23 |
Catalysis | Chapter 11, read articles on molecule of choice | first drafts due |
Oct |
30 | Membrane Proteins |
Chapter 12, read articles on molecule of choice | |
Nov |
6 | Signal Transduction |
Chapter 13, read articles on molecule of choice | |
Nov |
13 | Fibrous Proteins |
Chapter 14, read articles on molecule of choice | second drafts due |
Nov |
20 |
Immune System Molecules |
Chapter 15, read articles on molecule of choice | |
Nov | 27 | Practice Talk | prepare talks | |
Dec |
4 |
Presentation of Project |
final projects due |
linked resources... (clicking on the links below will open new browser windows)
The Online Macromolecular Museum - (see the WWW links section) |
RasMol Manual (detailed) - RasMol Manual (beginner's introduction) |
Protein Structure at ExPASy (see the "autopsy of a PDB file" - Chapter 11) |
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more coming soon.... |