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Chad L Barber, Ph.D.

Assistant Professor of Biology

Email: cbarber@callutheran.edu
Phone: (805) 493-3873
Office: ASCI 120
Curriculum Vitae: Download

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Before beginning his graduate work, Dr. Barber received a Masters from Cal. State Univ., Northridge (Master's candidate) in Biology, with a thesis focusing on reproductive biology, specifically sperm-egg interactions.  He then began a research stint at UCLA in the department of Radiation Biology for 2 years in the lab of Dr. William McBride and Dr. Keisuke Iwamoto.  Dr. Barber contributed to several publications with his work there and subsequently started a Ph.D. program at UCLA.

During his graduate work in the lab of Luisa Iruela-Arispe, Dr. Barber's research was in two main areas: vascular biology (the study of blood vessels and their formation) and developmental hematopoiesis (the generation of blood cells).  After completing his Ph.D. in Molecular Biology, he taught as a Lecturer at UCLA in several different courses including Developmental Biology and an honors course in Human Aging. In 2008,  he started a Post Doctoral Fellowship in the lab of Ken Dorshkind at UCLA. There he studyied lymphocyte progenitors and the molecular mechanisms in B cell differentiation.

Currently, Dr. Barber teaches several Introductory Biology lecture and lab courses, as well as upper division Cell Biology and Immunology.  

In addition to teaching, Dr. Barber conducts research in his laboratory with undergraduate students.  Mentored project areas include:

  • MicroRNA expression in smooth muscle cells and endothelial cells in response to integrin engagement.  
  • Effects of integrin inhibition on microRNA expression in cancer cells.
  • Differentiation of hematopoietic stem cells into B-1 lymphocytes in response to 3D culture conditions

Dr. Barber also developed and organizes the annual Cell Biology Symposium.  The half-day symposium includes research, public awareness and ethics seminars by leading experts and is held in early spring.  The 2014 topic was "In the Crosshairs: Targeting Cancer" and included 3 experts in cancer cell biology and novel research into treatments.

Education

  • 2013-2014: National Academy of Sciences Education Fellow 
  • 2011: Post-Doctoral Fellowship, Immunology, U.C.L.A. 
  • 2008: Ph.D., Molecular Biology, U.C.L.A.
  • 2000: M.S., Biology, California State University, Northridge.
  • 1997: B.S., Biology, Pepperdine University

Expertise

Stem cell biology, immunology, hematopoiesis (the process of generating blood cells from bone marrow stem cells), vascular biology, reproductive and developmental biology.  His research interests at C.L.U. include cell-cell and cell-matrix interactions and how they affect cell growth and differentiation. 

Publications


Jeanine M.L. Roodhart, Huanhuan He, Laura G.M. Daenen, Arnaud Monvoisin, Chad Barber, Miranda van Amersfoort, Jennifer J. Hofmann, Freddy Radtke, Timothy F. Lane, Emile E. Voest, M. Luisa Iruela-Arispe.  2013.  Notch1 regulates angio-supportive bone marrow-derived cells: relevance to chemoresistance.  Blood.  122(1):143-53.

Chad L. Barber, Encarnacion Montecino-Rodriguez, Kenneth Dorshkind. 2011. Developmental Relationships between B-1 and B-2 Progenitors.  Cell Cycle.  10(22): 3810-1.

Chad L. Barber, Encarnacion Montecino-Rodriguez, Kenneth Dorshkind. 2011. Reduced production of B-1 specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells. Proceedings of the National Academy of Sciences. 108 (33), 13700-13704.

Sunyoung Lee, Tom Chen, Chad L. Barber, Jared Murdock, Maria Jordan, Sharina Desai, Napoleone Ferrara, Andras Nagy, Kenneth Ross and M. Luisa Iruela-Arispe.  2007.  Autocrine VEGF Signaling is Required for Vascular Homeostasis.  Cell. 130, 691-703.

Keisuke S. Iwamoto and Chad L. Barber. 2007. Radiation-induced post-transcriptional control of M6P/IGF2r expression in breast cancer cell lines.  Molecular Carcinogenesis.  46(7): 497-502.

Chad L. Barber and M. Luisa Iruela-Arispe. 2006. The ever-elusive endothelial progenitor cell: identities, functions and clinical implications. Pediatric Research. 59(4 Pt 2): 26R-32R.

Keisuke S. Iwamoto, Shiho Yano, Chad L. Barber, Donald G. MacPhee, and Shoji Tokuoka. 2006. A Dose-Dependent Decrease in the Fraction of Cases Harboring M6P/IGF2R Mutations in Hepatocellular Carcinomas from the Atomic Bomb Survivors. Radiation Research. 166, 870–876.

Wen-Cheng Chen,William H. McBride,Keisuke S. Iwamoto, Chad L. Barber, Chun-Chieh Wang, Young-Taek Oh,Yu-Pei Liao,Ji-Hong Hong,Jean de Vellis,and Hungyi Shau 2002. Induction of radioprotective peroxiredoxin-I by ionizing irradiation. J. Neurosci. Res.;70(6):794-8.

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